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| HETEROLOGOUS PROTECTION AGAINST INFLUENZA BY INJECTION OF DNA ENCODING A VIRAL PROTEIN |
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| Author(s): ULMER JB, DONNELLY JJ, PARKER SE, RHODES GH, FELGNER PL, DWARKI VJ, GROMKOWSKI SH, DECK RR, DEWITT CM, FRIEDMAN A, HAWE LA, LEANDER KR, MARTINEZ D, PERRY HC, SHIVER JW, MONTGOMERY DL, LIU MA |
| Source: SCIENCE Volume: 259 Issue: 5102 Pages: 1745-1749 Published: MAR 19 1993 |
| Times Cited: 1,601 References: 60 |
| Abstract: Cytotoxic T lymphocytes (CTLs) specific for conserved viral antigens can respond to different strains of virus, in contrast to antibodies, which are generally strain-specific. The generation of such CTLs in vivo usually requires endogenous expression of the antigen, as occurs in the case of virus infection. To generate a viral antigen for presentation to the immune system without the limitations of direct peptide delivery or viral vectors, plasmid DNA encoding influenza A nucleoprotein was injected into the quadriceps of BALB/c mice. This resulted in the generation of nucleoprotein-specific CTLs and protection from a subsequent challenge with a heterologous strain of influenza A virus, as measured by decreased viral lung titers, inhibition of mass loss, and increased survival. |
| Document Type: Article |
| Language: English |
Addresses:
1. MERCK RES LABS, DEPT CANC RES, W POINT, PA 19486 USA
2. VICAL, SAN DIEGO, CA 92121 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: KT810 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |