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| HIGH-AFFINITY VEGF BINDING AND DEVELOPMENTAL EXPRESSION SUGGEST FLK-1 AS A MAJOR REGULATOR OF VASCULOGENESIS AND ANGIOGENESIS |
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| Author(s): MILLAUER B, WIZIGMANNVOOS S, SCHNURCH H, MARTINEZ R, MOLLER NPH, RISAU W, ULLRICH A |
| Source: CELL Volume: 72 Issue: 6 Pages: 835-846 Published: MAR 26 1993 |
| Times Cited: 1,339 References: 66 |
| Abstract: Examination of flk-1 receptor tyrosine kinase mRNA expression by in situ hybridization analysis revealed specific association with endothelial cells at all stages of mouse development, including the blood islands in the yolk sac of day 8.5-10.5 embryos, in which the early progenitors of this lineage originate. flk-1 transcripts were abundant in proliferating endothelial cells of vascular sprouts and branching vessels of embryonic and early postnatal brain, but were drastically reduced in adult brain, where proliferation has ceased. Identification of the angiogenic mitogen, vascular endothelial growth factor (VEGF), as the high affinity ligand of Flk-1 and correlation of the temporal and spatial expression pattern of Flk-1 and VEGF suggest a major role of this ligand-receptor signaling system in vasculogenesis and angiogenesis. |
| Document Type: Article |
| Language: English |
| Reprint Address: MILLAUER, B (reprint author), MAX PLANCK INST BIOCHEM, DEPT MOLEC BIOL, AM KLOPFERSPITZ 18A, W-8033 MARTINSRIED, GERMANY |
Addresses:
1. MAX PLANCK INST PSYCHIAT, DEPT NEUROCHEM, W-8033 MARTINSRIED, GERMANY
2. SUGEN INC, DEPT MOLEC BIOL, REDWOOD CITY, CA 94063 USA |
| Publisher: CELL PRESS, 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: KU175 |
| ISSN: 0092-8674 |
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