| | |  | | | | Record from Web of Science® | | | | | | |
| INFECTIOUS MORBIDITY AND DEFECTS OF PHAGOCYTIC FUNCTION IN END-STAGE RENAL-DISEASE - A REVIEW |
|
|
| Author(s): VANHOLDER R, RINGOIR S |
| Source: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY Volume: 3 Issue: 9 Pages: 1541-1554 Published: MAR 1993 |
| Times Cited: 116 References: 170 |
| Abstract: Infectious diseases remain among the most morbid events and are an important cause of death in ESRD. These events are related to an acquired immunodeficiency that progresses during the development of uremic retention, as part of the broader spectrum, displayed by the ''uremic syndrome''. A central role in the hose defense against bacterial infection is played by the phagocytic polymorphonuclear white blood cells, which are characterized by the capacity to ingest bacteria (phagocytosis), which is followed by the destruction of those bacteria (killing capacity). This article reviews the mechanisms of development and the potential causes that have been held responsible for this aspect of the defective immune function. The observed changes are attributed to alterations in receptor expression, although more convincing evidence points in the direction of metabolic functional disturbances, especially in the NAD(P)H-oxidase-dependent production of oxygen free radicals. The most important causative factors are: uremic toxicity, iron overload, renal anemia, dialyzer bioincompatibility, and the type of renal replacement therapy. It is concluded that the phagocytic defect in ESRD is multifactorial and that each factor should be managed by specific therapeutic approaches. |
| Document Type: Review |
| Language: English |
| Reprint Address: VANHOLDER, R (reprint author), STATE UNIV GHENT HOSP, DEPT NEPHROL, DE PINTELAAN 185, B-9000 GHENT, BELGIUM |
| Publisher: WILLIAMS & WILKINS, 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 |
| Subject Category: Urology & Nephrology |
| IDS Number: KV035 |
| ISSN: 1046-6673 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |