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| OVEREXPRESSION OF A M(R) 110,000 VESICULAR PROTEIN IN NON-P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE |
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| Author(s): SCHEPER RJ, BROXTERMAN HJ, SCHEFFER GL, KAAIJK P, DALTON WS, VANHEIJNINGEN THM, VANKALKEN CK, SLOVAK ML, DEVRIES EGE, VANDERVALK P, MEIJER CJLM, PINEDO HM |
| Source: CANCER RESEARCH Volume: 53 Issue: 7 Pages: 1475-1479 Published: APR 1 1993 |
| Times Cited: 432 References: 21 |
| Abstract: A M(r)110,000 protein (p110) is overexpressed in P-glycoprotein-negative multidrug-resistant tumor cell lines of different histogenetic origins. These cell lines show an ATP-dependent drug accumulation defect, suggesting the presence of drug transporter molecules different from P-glycoprotein. Immunohistochemical staining with a p110-specific monoclonal antibody (LRP-56) showed that, like P-glycoprotein, the molecule has a high expression in normal epithelial cells and tissues chronically exposed to xenobiotics and potentially toxic agents, such as bronchial cells, cells lining the intestines, and kidney tubules. Staining of LRP-56 is primarily cytoplasmic, in a coarsely granular fashion, indicating that it reacts with a molecule closely associated with vesicular/lysosomal structures. Involvement of p110 in the energy-dependent drug transport process present in the cell lines is unknown. |
| Document Type: Note |
| Language: English |
| Reprint Address: SCHEPER, RJ (reprint author), FREE UNIV AMSTERDAM HOSP, DEPT PATHOL, DE BOELELAAN 1117, 1081 HV AMSTERDAM, NETHERLANDS |
Addresses:
1. FREE UNIV AMSTERDAM HOSP, DEPT ONCOL, 1081 HV AMSTERDAM, NETHERLANDS
2. ARIZONA CANC CTR, TUCSON, AZ 85724 USA
3. CITY HOPE NATL MED CTR, DEPT CYTOGENET, DUARTE, CA 91010 USA
4. UNIV GRONINGEN HOSP, DEPT MED ONCOL, 9713 EZ GRONINGEN, NETHERLANDS |
| Publisher: AMER ASSOC CANCER RESEARCH, PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 |
| Subject Category: Oncology |
| IDS Number: KV615 |
| ISSN: 0008-5472 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |