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| CHROMOSOMAL LOCALIZATION OF 7 PAX GENES AND CLONING OF A NOVEL FAMILY MEMBER, PAX-9 |
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| Author(s): STAPLETON P, WEITH A, URBANEK P, KOZMIK Z, BUSSLINGER M |
| Source: NATURE GENETICS Volume: 3 Issue: 4 Pages: 292-298 Published: APR 1993 |
| Times Cited: 155 References: 44 |
| Abstract: In the human paired box-containing (PAX) gene family, only two members, PAX-3 and PAX-6, which are associated with Waardenburg's syndrome and aniridia, respectively have been mapped to human chromosomes. We have now isolated cosmids for six additional human PAX genes (PAX-1,-2,-5,-7,-8,-9) and a polymerase chain reaction fragment for PAX-4. PAX-9 is a novel family member which is closely related in its paired domain to PAX-1. The chromosomal location of all cloned PAX genes was determined by analysis of somatic cell hybrids and (except PAX-4) by fluorescence in situ hybridization to metaphase chromosomes. PAX-1 and PAX-7 map to chromosomal regions containing previously assigned disease loci. |
| Document Type: Article |
| Language: English |
Addresses:
1. RES INST MOLEC, PATHOL DR BOHR GASSE 7, A-1030 VIENNA, AUSTRIA |
| Publisher: NATURE PUBLISHING CO, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 |
| Subject Category: Genetics & Heredity |
| IDS Number: KW257 |
| ISSN: 1061-4036 |
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