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| ASTROCYTE EXPRESSION OF MESSENGER-RNA ENCODING CYTOKINES IP-10 AND JE/MCP-1 IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS |
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| Author(s): RANSOHOFF RM, HAMILTON TA, TANI M, STOLER MH, SHICK HE, MAJOR JA, ESTES ML, THOMAS DM, TUOHY VK |
| Source: FASEB JOURNAL Volume: 7 Issue: 6 Pages: 592-600 Published: APR 1 1993 |
| Times Cited: 369 References: 36 |
| Abstract: Mononuclear leukocytes preferentially accumulate in the central nervous system (CNS) during the course of experimental autoimmune encephalomyelitis (EAE). To address factors that govern leukocyte trafficking in EAE, we monitored expression of mRNAs encoding IP-10 and JE/MCP-1, which are members of a family of chemoattractant cytokines. A transient burst of IP-10 and JE/MCP-1 mRNA accumulation in the CNS occurred, in close relation to the onset of histologic and clinical disease. In situ hybridizations showed, unexpectedly, that astrocytes were the major source of mRNAs encoding IP-10 and JE/MCP-1. These observations implicate astrocyte-derived cytokines as potential chemoattractants for inflammatory cells during EAE. |
| Document Type: Note |
| Language: English |
| Reprint Address: RANSOHOFF, RM (reprint author), CLEVELAND CLIN FDN, RES INST, MELLEN CTR MULTIPLE SCLEROSIS TREATMENT & NEUROL, DEPT MOLEC BIOL, CLEVELAND, OH 44195 USA |
Addresses:
1. CLEVELAND CLIN FDN, DIV PATHOL & LAB MED, CLEVELAND, OH 44195 USA
2. CLEVELAND CLIN FDN, NEUROPATHOL SECT, CLEVELAND, OH 44195 USA |
| Publisher: FEDERATION AMER SOC EXP BIOL, 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 |
| Subject Category: Biochemistry & Molecular Biology; Biology; Cell Biology |
| IDS Number: KY009 |
| ISSN: 0892-6638 |
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