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| HUMAN MANNOSE-BINDING PROTEIN FUNCTIONS AS AN OPSONIN FOR INFLUENZA-A VIRUSES |
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| Author(s): HARTSHORN KL, SASTRY K, WHITE MR, ANDERS EM, SUPER M, EZEKOWITZ RA, TAUBER AI |
| Source: JOURNAL OF CLINICAL INVESTIGATION Volume: 91 Issue: 4 Pages: 1414-1420 Published: APR 1993 |
| Times Cited: 128 References: 29 |
| Abstract: Influenza A viruses (IAVs) cause substantial morbidity and mortality in yearly epidemics, which result from the ability of the virus to alter the antigenicity of its envelope proteins. Despite the rapid replication of this virus and its ability to infect a wide variety of cell types, viremia is rare and the infection is generally limited to the upper respiratory tract. The preimmune host defense response against IAV is generally, therefore, successful. We have previously provided (and summarized) evidence that neutrophils contribute to defense against IAV, although neutrophil dysfunction and local tissue damage may be less salutory byproducts of this response. Here we provide evidence that the serum lectin mannose-binding protein directly inhibits hemagglutinin activity and infectivity of several strains of IAV. In addition mannose-binding protein acts as an opsonin, enhancing neutrophil reactivity against IAV. Opsonization of IAV by mannose-binding protein also protects the neutrophil from IAV-induced dysfunction. These effects are observed with physiologically relevant concentrations of mannose-binding protein. Two different allelic forms of recombinant mannose-binding protein are found to have similar effects. We believe, on the basis of these data, that mannose-binding protein alone and in conjunction with phagocytic cells is an important constituent of natural immunity (i.e., preimmune defense) against IAV. |
| Document Type: Article |
| Language: English |
| Reprint Address: HARTSHORN, KL (reprint author), BOSTON UNIV, SCH MED, DEPT MED, 80 E CONCORD ST, BOSTON, MA 02118 USA |
Addresses:
1. BOSTON UNIV, SCH MED, DEPT PATHOL, BOSTON, MA 02118 USA
2. BOSTON CITY HOSP, DEPT MED, BOSTON, MA 02118 USA
3. HARVARD UNIV, SCH MED, DANA FARBER CANC INST, BOSTON, MA 02115 USA
4. HARVARD UNIV, CHILDRENS HOSP, DEPT PEDIAT, DIV HEMATOL ONCOL, BOSTON, MA 02115 USA
5. HARVARD UNIV, CHILDRENS HOSP, DEPT PEDIAT, DIV INFECT DIS, BOSTON, MA 02115 USA
6. UNIV MELBOURNE, DEPT MICROBIOL, PARKVILLE, VIC 3052 AUSTRALIA |
| Publisher: ROCKEFELLER UNIV PRESS, 1114 FIRST AVE, 4TH FL, NEW YORK, NY 10021 |
| Subject Category: Medicine, Research & Experimental |
| IDS Number: KY052 |
| ISSN: 0021-9738 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |