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| RELAXATION OF INSULIN-LIKE GROWTH FACTOR-II GENE IMPRINTING IMPLICATED IN WILMS-TUMOR |
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| Author(s): OGAWA O, ECCLES MR, SZETO J, MCNOE LA, YUN K, MAW MA, SMITH PJ, REEVE AE |
| Source: NATURE Volume: 362 Issue: 6422 Pages: 749-751 Published: APR 22 1993 |
| Times Cited: 540 References: 21 |
| Abstract: GENOMIC imprinting has been implicated in the onset of several embryonal tumours but the mechanism is not well understood1-3. Maternal chromosome 11p15 loss of heterozygosity4 and paternal chromosome 11 isodisomy 5,6 suggest that imprinted genes are involved in the onset of Wilms' tumour and the Beckwith-Wiedemann syndrome. The insulin-like growth factor II (IGF2) gene located at 11p15.5 has been put forward as a candidate gene as it is maternally imprinted (paternally expressed) in the mouse7, and is expressed at high levels in Wilms' tumours8,9. We report here that the IGF2 gene is expressed from the paternal allele in human fetal tissue, but that in Wilms' tumour expression can occur biallelically. These results provide, to our knowledge, the first evidence that relaxation of imprinting may play a role in the onset of disease and suggest a new genetic mechanism involved in the development of cancer. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV OTAGO, DEPT BIOCHEM, CANC GENET LAB, DUNEDIN, NEW ZEALAND
2. UNIV OTAGO, DEPT PATHOL, DUNEDIN, NEW ZEALAND
3. UNIV QUEENSLAND, DEPT PATHOL, HERSTON, QLD 4006 AUSTRALIA |
| Publisher: MACMILLAN MAGAZINES LTD, PORTERS SOUTH, 4 CRINAN ST, LONDON, ENGLAND N1 9XW |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: KY450 |
| ISSN: 0028-0836 |
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