| | |  | | | | Record from Web of Science® | | | | | | |
| TROPHIC EFFECT OF ERYTHROPOIETIN AND OTHER HEMATOPOIETIC FACTORS ON CENTRAL CHOLINERGIC NEURONS INVITRO AND INVIVO |
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| Author(s): KONISHI Y, CHUI DH, HIROSE H, KUNISHITA T, TABIRA T |
| Source: BRAIN RESEARCH Volume: 609 Issue: 1-2 Pages: 29-35 Published: APR 23 1993 |
| Times Cited: 164 References: 42 |
| Abstract: In vitro granulocyte colony-stimulating factor (G-CSF), macrophage colony-stimulating factor (M-CSF), erythropoietin (EPO), and erythroid differentiation factor (EDF) augmented choline acetyltransferase (ChAT) activity in mouse embryonic primary septal neurons and in cholinergic hybridoma cell line, SN6.10.2.2. This is similar to the effects seen with interleukin-3 (IL-3) or granulocyte-macrophage colony-stimulating factor (GM-CSF). Moreover, in vivo GM-CSF and EPO promoted survival of septal cholinergic neurons in adult rats which had undergone fimbria-fornix transections. These results suggest that some of the hematopoietic factors act on cholinergic neurons as 'neurotrophic factors' to influence the differentiation, maintenance and regeneration of these neurons. |
| Document Type: Article |
| Language: English |
Addresses:
1. NCNP, NATL INST NEUROSCI, DIV DEMYELINATING DIS & AGING, TOKYO 187, JAPAN
2. NITTA GELATIN INC, RES LAB, OSAKA, JAPAN |
| Publisher: ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS |
| Subject Category: Neurosciences |
| IDS Number: KY712 |
| ISSN: 0006-8993 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |