| | |  | | | | Record from Web of Science® | | | | | | |
| EXPERIMENTAL TRANSMISSION OF BSE AND SCRAPIE TO THE COMMON MARMOSET |
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| Author(s): BAKER HF, RIDLEY RM, WELLS GAH |
| Source: VETERINARY RECORD Volume: 132 Issue: 16 Pages: 403-406 Published: APR 17 1993 |
| Times Cited: 64 References: 27 |
| Abstract: Two young male common marmosets (Callithrix jacchus) were injected intracerebrally and intraperitoneally with a crude brain homogenate prepared from a cow with bovine spongiform encephalopathy (BSE). Two other marmosets were similarly injected with brain homogenate from a sheep with natural scrapie. The two animals injected with scrapie material developed neurological signs 38 and 42 months after injection and the two animals injected with BSE material developed neurological signs after 46 and 47 months. Post mortem examination of the brains revealed spongiform encephalopathy especially in the basal nuclei and diencephalon of all the animals and, in addition, involvement of the cerebral cortex of the marmosets injected with scrapie material. The experiment extends the host range of experimental BSE to include a primate species. |
| Document Type: Article |
| Language: English |
| Reprint Address: BAKER, HF (reprint author), CLIN RES CTR, DIV PSYCHIAT, WATFORD RD, HARROW HA1 3UJ, MIDDX ENGLAND |
Addresses:
1. MAFF, CENT VET LAB, DEPT PATHOL, WEYBRIDGE KT15 3NB, SURREY ENGLAND |
| Publisher: BRITISH VETERINARY ASSOC, 7 MANSFIELD ST, LONDON, ENGLAND W1M 0AT |
| Subject Category: Veterinary Sciences |
| IDS Number: KZ045 |
| ISSN: 0042-4900 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |