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| A MOLECULAR VARIANT OF ANGIOTENSINOGEN ASSOCIATED WITH PREECLAMPSIA |
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| Author(s): WARD K, HATA A, JEUNEMAITRE X, HELIN C, NELSON L, NAMIKAWA C, FARRINGTON PF, OGASAWARA M, SUZUMORI K, TOMODA S, BERREBI S, SASAKI M, CORVOL P, LIFTON RP, LALOUEL JM |
| Source: NATURE GENETICS Volume: 4 Issue: 1 Pages: 59-61 Published: MAY 1993 |
| Times Cited: 365 References: 23 |
| Abstract: Pregnancy-induced hypertension (PIH) is a heterogeneous disorder which complicates 5-7% of all pregnancies and remains a leading cause of maternal, fetal and neonatal morbidity and mortality. Severe preeclampsia is the most distinctive and life-threatening form; a multi-system disorder more common in first pregnancies, it is characterized by high blood pressure and proteinuria. In a series of Caucasian women with pregnancy-induced hypertension, we have observed a significant association of preeclampsia with a molecular variant of angiotensinogen, T235, found previously to be associated with essential hypertension. This finding is corroborated in a sample ascertained in Japan. Together, these observations support a new pathophysiological interpretation of preeclampsia and of its relation to some forms of essential hypertension. |
| Document Type: Article |
| Language: English |
| Reprint Address: WARD, K (reprint author), UNIV UTAH, SCH MED, DEPT OBSTET & GYNECOL, SALT LAKE CITY, UT 84132 USA |
Addresses:
1. NAGOYA CITY UNIV, SCH MED, DEPT BIOCHEM, MIZUHO KU, NAGOYA, AICHI 467 JAPAN
2. UNIV UTAH, SCH MED, HOWARD HUGHES MED INST, SALT LAKE CITY, UT 84112 USA
3. UNIV UTAH, SCH MED, ECCLES INST HUMAN GENET, DEPT HUMAN GENET, SALT LAKE CITY, UT 84112 USA
4. HOP BROUSSAIS, DEPT HYPERTENS, F-75674 PARIS 14, FRANCE
5. NAGOYA CITY UNIV, SCH MED, DEPT OBSTET & GYNECOL, MIZUHO KU, NAGOYA, AICHI 467 JAPAN
6. OSAKA CITY UNIV, SCH MED, DEPT OBSTET & GYNECOL, OSAKA 545, JAPAN
7. BRIGHAM & WOMENS HOSP, DIV ENDOCRINE HYPERTENS, BOSTON, MA 02115 USA
8. HARVARD UNIV, SCH MED, BOSTON, MA 02115 USA |
| Publisher: NATURE PUBLISHING CO, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 |
| Subject Category: Genetics & Heredity |
| IDS Number: LA337 |
| ISSN: 1061-4036 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |