| | |  | | | | Record from Web of Science® | | | | | | |
| ESTIMATION OF THE NUMBER OF NUCLEOTIDE SUBSTITUTIONS IN THE CONTROL REGION OF MITOCHONDRIAL-DNA IN HUMANS AND CHIMPANZEES |
|
|
| Author(s): TAMURA K, NEI M |
| Source: MOLECULAR BIOLOGY AND EVOLUTION Volume: 10 Issue: 3 Pages: 512-526 Published: MAY 1993 |
| Times Cited: 2,437 References: 34 |
| Abstract: Examining the pattern of nucleotide substitution for the control region of mitochondrial DNA (mtDNA) in humans and chimpanzees, we developed a new mathematical method for estimating the number of transitional and transversional substitutions per site, as well as the total number of nucleotide substitutions. In this method, excess transitions, unequal nucleotide frequencies, and variation of substitution rate among different sites are all taken into account. Application of this method to human and chimpanzee data suggested that the transition/transversion ratio for the entire control region was approximately 15 and nearly the same for the two species. The 95% confidence interval of the age of the common ancestral mtDNA was estimated to be 80,000-480,000 years in humans and 0.57-2.72 Myr in common chimpanzees. |
| Document Type: Article |
| Language: English |
Addresses:
1. PENN STATE UNIV, INST MOLEC EVOLUT GENET, 328 MUELLER LAB, UNIV PK, PA 16802 USA
2. PENN STATE UNIV, DEPT BIOL, UNIV PK, PA 16802 USA |
| Publisher: SOC MOLECULAR BIOLOGY EVOLUTION, PO BOX 1897, LAWRENCE, KS 66044-8897 |
| Subject Category: Biochemistry & Molecular Biology; Evolutionary Biology; Genetics & Heredity |
| IDS Number: LD114 |
| ISSN: 0737-4038 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |