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| ARE ESTROGENS INVOLVED IN FALLING SPERM COUNTS AND DISORDERS OF THE MALE REPRODUCTIVE-TRACT |
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| Author(s): SHARPE RM, SKAKKEBAEK NE |
| Source: LANCET Volume: 341 Issue: 8857 Pages: 1392-1395 Published: MAY 29 1993 |
| Times Cited: 1,071 References: 37 |
| Abstract: The incidence of disorders of development of the male reproductive tract has more than doubled in the past 30-50 years while sperm counts have declined by about half. Similar abnormalities occur in the sons of women exposed to diethylstilbestrol (DES) during pregnancy and can be induced in animals by brief exposure to exogenous oestrogen/DES during pregnancy. We argue that the increasing incidence of reproductive abnormalities in the human male may be related to increased oestrogen exposure in utero, and identify mechanisms by which this exposure could occur. |
| Document Type: Article |
| Language: English |
| Reprint Address: SHARPE, RM (reprint author), CTR REPROD BIOL, MRC, REPROD BIOL UNIT, 37 CHALMERS ST, EDINBURGH EH3 9EW, SCOTLAND |
Addresses:
1. UNIV COPENHAGEN, DEPT GROWTH & REPROD, DK-1168 COPENHAGEN, DENMARK |
| Publisher: LANCET LTD, 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL |
| Subject Category: Medicine, General & Internal |
| IDS Number: LE180 |
| ISSN: 0140-6736 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |