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| DECREASED DOPAMINE-D(2) RECEPTOR AVAILABILITY IS ASSOCIATED WITH REDUCED FRONTAL METABOLISM IN COCAINE ABUSERS |
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| Author(s): VOLKOW ND, FOWLER JS, WANG GJ, HITZEMANN R, LOGAN J, SCHLYER DJ, DEWEY SL, WOLF AP |
| Source: SYNAPSE Volume: 14 Issue: 2 Pages: 169-177 Published: JUN 1993 |
| Times Cited: 282 References: 80 |
| Abstract: Decreased dopaminergic function has been postulated to underlie cocaine addiction. To examine the possibility that dysfunction of brain regions subserved by the dopamine system could promote cocaine self-administration, positron emission tomography and a dual-tracer approach was used to examine dopamine D2 receptor availability and regional brain-glucose metabolism in cocaine abusers. When compared to normal controls, cocaine abusers showed significant decreases in dopamine D2 receptor availability which persisted 3-4 months after detoxification. Decreases in dopamine D2 receptor availability were associated with decreased metabolism in several regions of the frontal lobes, most markedly orbito-frontal cortex and cingulate gyri. Dopamine dysregulation of these brain areas which are involved in the channeling of drive and affect could lead to loss of control resulting in compulsive drug-taking behavior. |
| Document Type: Article |
| Language: English |
| Reprint Address: VOLKOW, ND (reprint author), BROOKHAVEN NATL LAB, DEPT MED, UPTON, NY 11973 USA |
Addresses:
1. BROOKHAVEN NATL LAB, DEPT CHEM, UPTON, NY 11973 USA
2. SUNY, DEPT PSYCHIAT, STONY BROOK, NY 11794 USA
3. VET ADM MED CTR, NORTHPORT, NY 11768 USA |
| Publisher: WILEY-LISS, DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 |
| Subject Category: Neurosciences |
| IDS Number: LE224 |
| ISSN: 0887-4476 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |