| | |  | | | | Record from Web of Science® | | | | | | |
| CELLULAR ACCUMULATION OF THE ANTICANCER AGENT CISPLATIN - A REVIEW |
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| Author(s): GATELY DP, HOWELL SB |
| Source: BRITISH JOURNAL OF CANCER Volume: 67 Issue: 6 Pages: 1171-1176 Published: JUN 1993 |
| Times Cited: 291 References: 42 |
| Abstract: Acquired resistance to cisplatin (DDP) is a major clinical problem in the treatment of ovarian, testicular, and head and neck carcinomas; decreased accumulation of DDP is the most consistently observed alteration in resistant cells. It has been postulated that DDP enters the cell by passive diffusion based on the observations that DDP accumulation is proportional to the drug concentration, accumulation is not saturable, and that structural analogs of DDP do not inhibit accumulation. However, recent studies show that DDP accumulation can be specifically stimulated or inhibited by pharmacological agents and the activation of signal transduction pathways. This paper reviews the existing data on the mechanism of DDP accumulation and develops the postulate that' some component of transport occurs through a gated ion channel. |
| Document Type: Review |
| Language: English |
| Reprint Address: GATELY, DP (reprint author), UNIV CALIF SAN DIEGO, DEPT BIOMED SCI, LA JOLLA, CA 92093 USA |
Addresses:
1. UNIV CALIF SAN DIEGO, DEPT MED, LA JOLLA, CA 92093 USA |
| Publisher: STOCKTON PRESS, HOUNDMILLS, BASINGSTOKE, HAMPSHIRE, ENGLAND RG21 6XS |
| Subject Category: Oncology |
| IDS Number: LF319 |
| ISSN: 0007-0920 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |