| | |  | | | | Record from Web of Science® | | | | | | |
| A SINGLE PREEXPOSURE PRODUCES SENSITIZATION TO THE LOCOMOTOR EFFECTS OF COCAINE IN MICE |
|
|
| Author(s): JACKSON HC, NUTT DJ |
| Source: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR Volume: 45 Issue: 3 Pages: 733-735 Published: JUL 1993 |
| Times Cited: 38 References: 7 |
| Abstract: Sensitization to the locomotor effects of cocaine (10 mg/kg, IP) occurred in mice following preexposure to a single high dose (40 mg/kg, IP) of the drug on the previous day. Behavioral sensitization only occurred under certain experimental conditions; that is, in mice which were injected in a novel environment (i.e., the activity boxes) on day 1 and tested in the same environment on day 2. It did not occur in mice that were fully habituated to the test apparatus on both days of the experiment or in mice that were injected in the home cage on day 1. This model is consistent with studies in rats, and offers the opportunity for further characterization of the processes underlying cocaine sensitization. |
| Document Type: Article |
| Language: English |
Addresses:
1. SCH MED SCI, DEPT PHARMACOL, RECKITT & COLMAN PSYCHOPHARMACOL UNIT, BRISTOL BS8 1TD, ENGLAND |
| Publisher: PERGAMON-ELSEVIER SCIENCE LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB |
| Subject Category: Behavioral Sciences; Neurosciences; Pharmacology & Pharmacy |
| IDS Number: LH047 |
| ISSN: 0091-3057 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |