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| FUSION OF CHOP TO A NOVEL RNA-BINDING PROTEIN IN HUMAN MYXOID LIPOSARCOMA |
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| Author(s): CROZAT A, AMAN P, MANDAHL N, RON D |
| Source: NATURE Volume: 363 Issue: 6430 Pages: 640-644 Published: JUN 17 1993 |
| Times Cited: 414 References: 18 |
| Abstract: HUMAN myxoid liposarcomas contain a characteristic chromosomal translocation, t(12;16)(q13;p11)1,2, that is associated with a structural rearrangement of the gene encoding CHOP 3, a growth arrest and DNA-damage inducible member of the C/EBP family of transcription factors4,5 residing on 12q13.1 6. Using a CHOP-specific complementary probe and antiserum we report here the presence of an abnormal CHOP transcript and protein in these tumours. Cloning of the translocation-associated CHOP gene product revealed a fusion between CHOP and a gene provisionally named TLS (translocated in liposarcoma). TLS is a novel nuclear RNA-binding protein with extensive sequence similarity to EWS7, the product of a gene commonly translocated in Ewing's sarcoma. In TLS-CHOP the RNA-binding domain of TLS is replaced by the DNA-binding and leucine zipper dimerization domain of CHOP. Targeting of a conserved effector domain of RNA-binding proteins to DNA may play a role in tumour formation. |
| Document Type: Article |
| Language: English |
| Reprint Address: CROZAT, A (reprint author), NYU MED CTR, DEPT MED, NEW YORK, NY 10016 USA |
Addresses:
1. NYU MED CTR, DEPT CELL BIOL, NEW YORK, NY 10016 USA
2. NYU MED CTR, KAPLAN CANC CTR, NEW YORK, NY 10016 USA
3. UNIV LUND HOSP, DEPT CLIN GENET, S-22185 LUND, SWEDEN |
| Publisher: MACMILLAN MAGAZINES LTD, PORTERS SOUTH, 4 CRINAN ST, LONDON, ENGLAND N1 9XW |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: LH139 |
| ISSN: 0028-0836 |
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