| | |  | | | | Record from Web of Science® | | | | | | |
| CELL-MEDIATED CYTOTOXICITY - CONTACT AND SECRETED FACTORS |
|
|
| Author(s): APASOV S, REDEGELD F, SITKOVSKY M |
| Source: CURRENT OPINION IN IMMUNOLOGY Volume: 5 Issue: 3 Pages: 404-410 Published: JUN 1993 |
| Times Cited: 55 References: 72 |
| Abstract: The list of cells with cytotoxic potential now may include small resting T cells, but the exact nature of 'lethal hit delivery' by cytotoxic T lymphocytes remains elusive. Cell-mediated cytotoxicity by cytotoxic T lymphocytes is a complex, multistep process which seems likely to be mediated by several different pathways. Recent experimental evidence for the functioning of a novel cytotoxic mechanism through a target cell's surface receptor illustrates and emphasizes the necessity to study the interactions of cytotoxic T lymphocytes and target cells as a whole. Progress is evident in the description of molecular requirements for triggering cytotoxicity, cell-cell contacts and the regulation of the effector responses of cytotoxic T lymphocytes by extracellular, intracellular and granular proteins. Extracellular Ca2+-dependent secretion of perforin and protease(s) may explain several aspects of cellular cytotoxicity, whereas the apoptosis-mediating cell surface Fas protein is now implicated in Ca2+-independent cytotoxicity. |
| Document Type: Review |
| Language: English |
| Reprint Address: APASOV, S (reprint author), NIAID, IMMUNOL LAB, ROOM 11N-311, BLDG 10, BETHESDA, MD 20892 USA |
| Publisher: CURRENT BIOLOGY LTD, 34-42 CLEVELAND STREET, LONDON, ENGLAND W1P 6LB |
| Subject Category: Immunology |
| IDS Number: LH451 |
| ISSN: 0952-7915 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |