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| 3,400 NEW EXPRESSED SEQUENCE TAGS IDENTIFY DIVERSITY OF TRANSCRIPTS IN HUMAN BRAIN |
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| Author(s): ADAMS MD, KERLAVAGE AR, FIELDS C, VENTER JC |
| Source: NATURE GENETICS Volume: 4 Issue: 3 Pages: 256-267 Published: JUL 1993 |
| Times Cited: 283 References: 30 |
| Abstract: We present the results of the partial sequencing of over 3,400 expressed sequence tags (ESTs) from human brain cDNA clones, which increases the number of distinct genes expressed in the brain, that are represented by ESTs, to about 6,000. By choosing clones in an unbiased manner, it is possible to construct a profile of the transcriptional activity of the brain at different stages. Proteins that comprise the cytoskeleton are the most abundant; however, a large variety of regulatory proteins are also seen. About half of the ESTs predicted to contain a protein-coding region have no matches in the public peptide databases and may represent new gene families. |
| Document Type: Article |
| Language: English |
| Reprint Address: ADAMS, MD (reprint author), INST GENOM RES, 932 CLOPPER RD, GAITHERSBURG, MD 20878 USA |
Addresses:
1. NINCDS, RECEPTOR BIOCHEM & MOLECU BIOL SECT, BETHESDA, MD 20892 USA |
| Publisher: NATURE PUBLISHING CO, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 |
| Subject Category: Genetics & Heredity |
| IDS Number: LJ842 |
| ISSN: 1061-4036 |
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