| | |  | | | | Record from Web of Science® | | | | | | |
| PROLIFERATIVE ACTIVITY IN THE KIDNEYS OF AGING MICE EVALUATED BY PCNA/CYCLIN IMMUNOHISTOCHEMISTRY |
|
|
| Author(s): HANAI T, USUDA N, MORITA T, SHIMIZU T, NAGATA T |
| Source: CELLULAR AND MOLECULAR BIOLOGY Volume: 39 Issue: 2 Pages: 181-191 Published: MAR 1993 |
| Times Cited: 20 References: 33 |
| Abstract: The change of proliferative activity in mouse kidney cortex cells due to aging was studied by PCNA/cyclin immunostaining. Mouse kidney tissues of various ages: late fetal, newborn, suckling, weaning, adult and senescent were used for this experiment. Small pieces of kidney tissues were fixed in methacarn solution and embedded in paraffin. Sections were stained with PCNA/cyclin monoclonal antibody. The reaction product for PCNA/cyclin was observed mainly on nuclei. The ratio of the PCNA/cyclin positive nuclei to the total number of nuclei were calculated. PCNA/cyclin positive ratios in glomeruli and uriniferous tubules in the superficial layer were higher than those in the deep layer from late fetal period to suckling period. They decreased due to aging after birth and became to nearly zero after weaning period. |
| Document Type: Article |
| Language: English |
| Reprint Address: HANAI, T (reprint author), SHINSHU UNIV, SCH MED, DEPT ANAT & CELL BIOL, MATSUMOTO, NAGANO 390 JAPAN |
Addresses:
1. SHINSHU UNIV, SCH MED, DEPT SURG, MATSUMOTO, NAGANO 390 JAPAN |
| Publisher: CELLULAR & MOLECULAR BIOLOGY, PROF R WEGMANN RESIDENCE HAUSSMANN 1 AVENUE DU PAVE NEUF, 93160 NOISY-LE-GRAND, FRANCE |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: LK210 |
| ISSN: 0145-5680 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |