| | |  | | | | Record from Web of Science® | | | | | | |
| THE T(8-21) TRANSLOCATION IN ACUTE MYELOID-LEUKEMIA RESULTS IN PRODUCTION OF AN AML1-MTG8 FUSION TRANSCRIPT |
|
|
| Author(s): MIYOSHI H, KOZU T, SHIMIZU K, ENOMOTO K, MASEKI N, KANEKO Y, KAMADA N, OHKI M |
| Source: EMBO JOURNAL Volume: 12 Issue: 7 Pages: 2715-2721 Published: JUL 1993 |
| Times Cited: 361 References: 36 |
| Abstract: The t(8;21) translocation is one of the most frequent chromosome abnormalities in acute myeloid leukemia. It has been shown that the t(8;21) breakpoints on chromosome 21 cluster within a single specific intron of the AML1 gene, which is highly homologous to the Drosophila segmentation gene runt. Here we report that this translocation juxtaposes the AML1 gene with a novel gene, named MTG8, on chromosome 8, resulting in the synthesis of an AML1-MTG8 fusion transcript. The fusion protein predicted by the AML1-MTG8 transcript consists of the runt homology region of AML1 and the most part of MTG8, which contains putative zinc ringer DNA binding motifs and proline-rich regions constituting a characteristic feature of transcription factors. The MTG8 gene is not expressed in normal hematopoietic cells, whereas AML1 is expressed at high levels. Our results indicate that the production of chimeric AML1-MTG8 protein, probably a chimeric transcription factor, may contribute to myeloid leukemogenesis. |
| Document Type: Article |
| Language: English |
| Reprint Address: MIYOSHI, H (reprint author), SAITAMA CANC CTR, DEPT IMMUNOL & VIROL, INA, SAITAMA 362 JAPAN |
Addresses:
1. SAITAMA CANC CTR HOSP, HEMATOL CLIN, INA, SAITAMA 362 JAPAN
2. HIROSHIMA UNIV, NUCL MED & BIOL RES INST, DEPT HEMATOL, HIROSHIMA 734, JAPAN |
| Publisher: OXFORD UNIV PRESS UNITED KINGDOM, WALTON ST JOURNALS DEPT, OXFORD, ENGLAND OX2 6DP |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: LK364 |
| ISSN: 0261-4189 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |