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POLYCHEMOTHERAPY IN ADVANCED NON-SMALL-CELL LUNG-CANCER - A METAANALYSIS
Author(s): SOUQUET PJ, CHAUVIN F, BOISSEL JP, CELLERINO R, CORMIER Y, GANZ PA, KAASA S, PATER JL, QUOIX E, RAPP E, TUMARELLO D, WILLIAMS J, WOODS BL, BERNARD JP
Source: LANCET    Volume: 342    Issue: 8862    Pages: 19-21    Published: JUL 3 1993  
Times Cited: 423     References: 19     
Abstract: We did a meta-analysis of all published polychemotherapy vs supportive care clinical trials in patients with non-resectable non small cell lung cancer. 7 studies with more than 700 patients were selected. We used the number of deaths at 3, 6, 9, 12, and 18 months as the endpoints because we were unable to obtain all the individual data. Our analysis showed a reduction in mortality during the first 6 months with polychemotherapy. Although small, this increase in survival, together with an improved quality of life, suggests that polychemotherapy should be recommended for patients with non-resectable non small cell lung cancer.
Document Type: Article
Language: English
Reprint Address: SOUQUET, PJ (reprint author), CTR HOSP LYON SUD, SERV PNEUMOL, F-69310 PIERRE BENITE, FRANCE
Addresses:
1. UNITE PHARMACOL CLIN, LYON, FRANCE
2. HOP LAVAL, CTR PNEUMOL, QUEBEC CITY, PQ CANADA
3. UCLA, DEPT MED, LOS ANGELES, CA USA
4. CTR HOSP STRASBOURG, SERV PNEUMOL, STRASBOURG, FRANCE
5. ROYAL N SHORE HOSP, DEPT CLIN ONCOL, SYDNEY, AUSTRALIA
6. TOM BAKER CANC CLIN, CALGARY, AB CANADA
7. SOUTHAMPTON GEN HOSP, CRC, SOUTHAMPTON SO9 4XY, HANTS ENGLAND
8. UNIV ANCONA, ONCOL CLIN, I-60100 ANCONA, ITALY
9. NORWEGIAN RADIUM HOSP, OSLO 3, NORWAY
10. QUEENS UNIV, NCI, CANADA CLIN TRIALS GRP, KINGSTON K7L 3N6, ONTARIO CANADA
Publisher: LANCET LTD, 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL
Subject Category: Medicine, General & Internal
IDS Number: LK985
ISSN: 0140-6736
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