| | |  | | | | Record from Web of Science® | | | | | | |
| A LINKAGE BETWEEN DNA MARKERS ON THE X-CHROMOSOME AND MALE SEXUAL ORIENTATION |
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| Author(s): HAMER DH, HU S, MAGNUSON VL, HU N, PATTATUCCI AML |
| Source: SCIENCE Volume: 261 Issue: 5119 Pages: 321-327 Published: JUL 16 1993 |
| Times Cited: 346 References: 51 |
| Abstract: The role of genetics in male sexual orientation was investigated by pedigree and linkage analyses on 114 families of homosexual men. Increased rates of same-sex orientation were found in the maternal uncles and male cousins of these subjects, but not in their fathers or paternal relatives, suggesting the possibility of sex-linked transmission in a portion of the population. DNA linkage analysis of a selected group of 40 families in which there were two gay brothers and no indication of nonmaternal transmission revealed a correlation between homosexual orientation and the inheritance of polymorphic markers on the X chromosome in approximately 64 percent of the sib-pairs tested. The linkage to markers on Xq28, the subtelomeric region of the long arm of the sex chromosome, had a multipoint lod score of 4.0 (P = 10(-5)), indicating a statistical confidence level of more than 99 percent that at least one subtype of male sexual orientation is genetically influenced. |
| Document Type: Article |
| Language: English |
| Reprint Address: HAMER, DH (reprint author), NCI, BIOCHEM LAB, BETHESDA, MD 20892 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: LM678 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |