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| CALCIUM MOBILIZATION BY DUAL RECEPTORS DURING FERTILIZATION OF SEA-URCHIN EGGS |
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| Author(s): LEE HC, AARHUS R, WALSETH TF |
| Source: SCIENCE Volume: 261 Issue: 5119 Pages: 352-355 Published: JUL 16 1993 |
| Times Cited: 249 References: 25 |
| Abstract: Fertilization is accompanied by a transient increase in the concentration of intracellular Ca2+, which serves as a signal for initiating development. Some of the Ca2+ appears to be released from intracellular stores by the binding of inositol trisphosphate (IP3) to its receptor. However, in sea urchin eggs, other mechanisms appear to participate. Cyclic adenosine diphosphate-ribose (cADPR), a naturally occurring metabolite of nicotinamide adenine dinucleotide, is as potent as IP3 in mobilizing Ca2+ in sea urchin eggs. Experiments with antagonists of the cADPR and IP3 receptors revealed that both Ca2+ mobilizing systems were activated during fertilization. Blockage of either of the systems alone was not sufficient to prevent the sperm-induced Ca2+ transient. This study provides direct evidence for a physiological role of cADPR in the Ca2+ signaling process. |
| Document Type: Article |
| Language: English |
| Reprint Address: LEE, HC (reprint author), UNIV MINNESOTA, DEPT PHYSIOL, MINNEAPOLIS, MN 55455 USA |
Addresses:
1. UNIV MINNESOTA, DEPT PHARMACOL, MINNEAPOLIS, MN 55455 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: LM678 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |