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| A HOMEOTIC GENE-CLUSTER PATTERNS THE ANTEROPOSTERIOR BODY AXIS OF C-ELEGANS |
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| Author(s): WANG BB, MULLERIMMERGLUCK MM, AUSTIN J, ROBINSON NT, CHISHOLM A, KENYON C |
| Source: CELL Volume: 74 Issue: 1 Pages: 29-42 Published: JUL 16 1993 |
| Times Cited: 237 References: 50 |
| Abstract: In insects and vertebrates, clusters of Antennapedia class homeobox (HOM-C) genes specify anteroposterior body pattern. The nematode C. elegans also contains a small cluster of HOM-C genes, one of which has been shown to specify positional identity. Here we show that two additional C. elegans HOM-C genes also specify positional identity and that together these three HOM-C genes function along the anteroposterior axis in the same order as their homologs in other organisms. Thus, HOM-C-based pattern formation has been conserved in nematodes despite the many differences in morphology and embryology that distinguish them from other phyla. Each C. elegans HOM-C gene is responsible for a distinct body region; however, where their domains overlap, two HOM-C genes can act together to specify the fates of individual cells. |
| Document Type: Article |
| Language: English |
| Reprint Address: WANG, BB (reprint author), UNIV CALIF SAN FRANCISCO, DEPT BIOCHEM & BIOPHYS, SAN FRANCISCO, CA 94143 USA |
Addresses:
1. MRC, MOLEC BIOL LAB, CAMBRIDGE CB2 2QH, ENGLAND |
| Publisher: CELL PRESS, 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: LN625 |
| ISSN: 0092-8674 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |