| ENHANCEMENT OF BM ALLOGRAFTING FROM C57BL/6 NUDE-MICE INTO C3H/HEJ RECIPIENTS BY TOLERIZED T-CELLS FROM (C57BL/6-]C3H/HEJ) AND (C3H/HEJ-]C57BL/6) CHIMERAS |
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| Author(s): FAKTOROWICH Y, LAPIDOT T, LUBIN I, REISNER Y |
| Source: BONE MARROW TRANSPLANTATION Volume: 12 Issue: 1 Pages: 15-20 Published: JUL 1993 |
| Times Cited: 7 References: 24 |
| Abstract: The possible participation of T cells in the promotion of hematopoietic engraftment of BM allografts, as opposed to their potential role in overcoming host-versus-graft reactions, was investigated recently by using (host X donor)F1 T cells devoid of graft-versus-host activity. In the present study, we provide further evidence of this effect by using tolerized thymocytes from established allogeneic chimeras. We show that tolerant mature thymocytes from donor type (C57BL/6 --> C3H/HeJ) or host type (C3H/HeJ --> C57BL/6) chimeras are as effective as (donor x host)F1 thymocytes in promoting both short-term and long-term engraftment of C57BL/6-Nu/Nu T cell-depleted BM cells in lethally irradiated C3H/HeJ recipients. |
| Document Type: Article |
| Language: English |
Addresses:
1. WEIZMANN INST SCI, DEPT MEMBRANE RES & BIOPHYS, IL-76100 REHOVOT, ISRAEL |
| Publisher: STOCKTON PRESS, HOUNDMILLS, BASINGSTOKE, HAMPSHIRE, ENGLAND RG21 6XS |
| Subject Category: Biophysics; Oncology; Hematology; Immunology; Transplantation |
| IDS Number: LP077 |
| ISSN: 0268-3369 |