| | |  | | | | Record from Web of Science® | | | | | | |
| NO EVIDENCE FOR LINKAGE TO THE TYPE-1 OR TYPE-2 NEUROFIBROMATOSIS LOCI IN NOONAN SYNDROME FAMILIES |
|
|
| Author(s): FLINTOFF WF, BAHUAU M, LYONNET S, GILGENKRANTZ S, LACOMBE D, MARCON F, LEVILLIERS J, KACHANER J, MUNNICH A, LEMERRER M |
| Source: AMERICAN JOURNAL OF MEDICAL GENETICS Volume: 46 Issue: 6 Pages: 700-705 Published: JUL 1 1993 |
| Times Cited: 16 References: 30 |
| Abstract: A linkage analysis has been performed on 6 two-generation families with classical Noonan syndrome to determine whether the syndrome is linked to neurofibromatosis type 1 on chromosome 17q or to neurofibromatosis type 2 on chromosome 22q. A significantly negative location score was obtained between 10 cM centromeric to and 15 cM telomeric from the neurofibromatosis type 1 locus. A significantly negative lod score was obtained with a marker mapping within the region where neurofibromatosis type 2 is thought to be located. These data indicate that Noonan syndrome is not tightly linked to either neurofibromatosis type 1 or type 2. (C) 1993 Wiley-Liss, Inc. |
| Document Type: Article |
| Language: English |
Addresses:
1. INSERM, UNITE RECH HANDICAPS GENET ENFANT U12, 149 RUE SEVRES, F-75743 PARIS 15, FRANCE
2. HOP ENFANTS MALAD, SERV CARDIOL, PARIS, FRANCE
3. INST PASTEUR, UNITE MOLEC HUMAINE, F-75724 PARIS 15, FRANCE
4. CRTS, GENET LAB, NANCY, FRANCE
5. CHU BORDEAUX, SERV PEDIAT & GENET, BORDEAUX, FRANCE
6. CHU NANCY BRABOIS, SERV CARDIOL INFANTILE, NANCY, FRANCE
7. UNIV WESTERN ONTARIO, DEPT MICROBIOL & IMMUNOL, LONDON N6A 3K7, ONTARIO CANADA |
| Publisher: WILEY-LISS, DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 |
| Subject Category: Genetics & Heredity |
| IDS Number: LP905 |
| ISSN: 0148-7299 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |