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| POLYGENIC CONTROL OF AUTOIMMUNE DIABETES IN NONOBESE DIABETIC MICE |
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| Author(s): GHOSH S, PALMER SM, RODRIGUES NR, CORDELL HJ, HEARNE CM, CORNALL RJ, PRINS JB, MCSHANE P, LATHROP GM, PETERSON LB, WICKER LS, TODD JA |
| Source: NATURE GENETICS Volume: 4 Issue: 4 Pages: 404-409 Published: AUG 1993 |
| Times Cited: 257 References: 38 |
| Abstract: Partial exclusion mapping of the nonobese (NOD) diabetic mouse genome has shown linkage of diabetes to at least five different chromosomes. We have now excluded almost all of the genome for the presence of susceptibility genes with fully recessive effects and have obtained evidence of linkage of ten distinct loci to diabetes or the prediabetic lesion, insulitis, indicative of a polygenic mode of inheritance. The relative importance of these loci and their interactions have been assessed using a new application of multiple polychotomous regression methods. A candidate disease gene, interleukin-2 (Il-2), which is closely linked to insulitis and diabetes, is shown to have a different sequence in NOD, including an insertion and a deletion of tandem repeat sequences which encode amino acid repeats in the mature protein. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV OXFORD, JOHN RADCLIFFE HOSP, NUFFIELD DEPT SURG, OXFORD OX3 9DU, ENGLAND
2. INSERM, F-75010 PARIS, FRANCE
3. MERCK RES LABS, DEPT CELLULAR & MOLEC PHARMACOL, RAHWAY, NJ 07065 USA
4. MERCK RES LABS, DEPT AUTOIMMUNE DIS RES, RAHWAY, NJ USA |
| Publisher: NATURE PUBLISHING CO, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 |
| Subject Category: Genetics & Heredity |
| IDS Number: LQ178 |
| ISSN: 1061-4036 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |