| THE WT1 WILMS-TUMOR GENE-PRODUCT - A DEVELOPMENTALLY-REGULATED TRANSCRIPTION FACTOR IN THE KIDNEY THAT FUNCTIONS AS A TUMOR-SUPPRESSOR |
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| Author(s): RAUSCHER FJ |
| Source: FASEB JOURNAL Volume: 7 Issue: 10 Pages: 896-903 Published: JUL 1993 |
| Times Cited: 195 References: 67 |
| Abstract: Alteration of transcription factor function is becoming a common theme in molecular mechanisms of oncogenesis. A recent example of this trend is the isolation and characterization of the chromosome 11p13 Wilms tumor suppressor gene, WT1. The WT1 protein contains a DNA binding domain consisting of four zinc fingers of the Cys2-His2 class and a proline-glutamine rich region capable of regulating transcription. Deletions of the WT1 gene or point mutations which destroy the DNA binding activity of the protein are associated with the development of the pediatric nephroblastoma Wilms tumor and Denys-Drash syndrome. This article reviews the role of WT1 in normal kidney development processes, the known biochemical functions of the protein and the status of identifying target genes regulated by this potentially oncogenic transcription factor. |
| Document Type: Review |
| Language: English |
| Reprint Address: RAUSCHER, FJ (reprint author), WISTAR INST ANAT & BIOL, 3601 SPRUCE ST, PHILADELPHIA, PA 19104 USA |
| Publisher: FEDERATION AMER SOC EXP BIOL, 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 |
| Subject Category: Biochemistry & Molecular Biology; Biology; Cell Biology |
| IDS Number: LQ337 |
| ISSN: 0892-6638 |