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| GENE DOSE OF APOLIPOPROTEIN-E TYPE-4 ALLELE AND THE RISK OF ALZHEIMERS-DISEASE IN LATE-ONSET FAMILIES |
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| Author(s): CORDER EH, SAUNDERS AM, STRITTMATTER WJ, SCHMECHEL DE, GASKELL PC, SMALL GW, ROSES AD, HAINES JL, PERICAKVANCE MA |
| Source: SCIENCE Volume: 261 Issue: 5123 Pages: 921-923 Published: AUG 13 1993 |
| Times Cited: 3,318 References: 23 |
| Abstract: The apolipoprotein E type 4 allele (APOE-epsilon4) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease (AD). Risk for AD increased from 20% to 90% and mean age at onset decreased from 84 to 68 years with increasing number of APOE-epsilon4 alleles in 42 families with late onset AD. Thus APOE-epsilon4 gene dose is a major risk factor for late onset AD and, in these families, homozygosity for APOE-epsilon4 was virtually sufficient to cause AD by age 80. |
| Document Type: Article |
| Language: English |
Addresses:
1. DUKE UNIV, MED CTR, JOSEPH & KATHLEEN BRYAN ALZHEIMERS DIS RES CTR, DEPT MED, DURHAM, NC 27710 USA
2. DUKE UNIV, MED CTR, JOSEPH & KATHLEEN BRYAN ALZEHEIMERS DIS RES CTR, DEPT NEUROL, DURHAM, NC 27710 USA
3. DUKE UNIV, MED CTR, JOSEPH & KATHLEEN BRYAN ALZEHEIMERS DIS RES CTR, DEPT NEUROBIOL, DURHAM, NC 27710 USA
4. VET ADM MED CTR, DURHAM, NC 27705 USA
5. UNIV CALIF LOS ANGELES, CTR HLTH SCI, NEUROPSYCHIAT INST & HOSP, LOS ANGELES, CA 90024 USA
6. MASSACHUSETTS GEN HOSP, MOLEC NEUROGENET UNIT, BOSTON, MA 02129 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: LR897 |
| ISSN: 0036-8075 |
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