| | |  | | | | Record from Web of Science® | | | | | | |
| PROTEIN KINASE-C-ZETA ISOFORM IS CRITICAL FOR MITOGENIC SIGNAL-TRANSDUCTION |
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| Author(s): BERRA E, DIAZMECO MT, DOMINGUEZ I, MUNICIO MM, SANZ L, LOZANO J, CHAPKIN RS, MOSCAT J |
| Source: CELL Volume: 74 Issue: 3 Pages: 555-563 Published: AUG 13 1993 |
| Times Cited: 362 References: 32 |
| Abstract: The requirement of protein kinase C zeta(zetaPKC) for maturation of X. laevis oocytes in response to insulin, p21ras, and phosphatidylcholine-hydrolyzing phospholipase C has recently been shown. Here we present experimental evidence demonstrating that activation of zetaPKC is not only necessary but also sufficient by itself to activate maturation in oocytes and to produce deregulation of growth control in mouse fibroblasts. Furthermore, by using a dominant kinase-defective mutant zetaPKC, we confirm that this kinase is required for mitogenic activation in oocytes and fibroblasts. These results permit us to propose zetaPKC as a critical step downstream of p21ras in mitogenic signal transduction. |
| Document Type: Article |
| Language: English |
| Reprint Address: BERRA, E (reprint author), UNIV AUTONOMA MADRID, CSIC, CTR BIOL MOLEC, CANTO BLANCO, E-28049 MADRID, SPAIN |
| Publisher: CELL PRESS, 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: LT739 |
| ISSN: 0092-8674 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |