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| FURTHER EVIDENCE FOR THE EXISTENCE OF A CLONAL PH-NEGATIVE STAGE IN SOME CASES OF PH-POSITIVE CHRONIC MYELOCYTIC-LEUKEMIA |
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| Author(s): RASKIND WH, FERRARIS AM, NAJFELD V, JACOBSON RJ, MOOHR JW, FIALKOW PJ |
| Source: LEUKEMIA Volume: 7 Issue: 8 Pages: 1163-1167 Published: AUG 1993 |
| Times Cited: 45 References: 33 |
| Abstract: The Ph chromosome abnormality is involved in the pathogenesis of almost all patients with chronic myelocytic leukemia (CML). Previous studies on the B-lymphoid cell lineage in two patients with Ph-positive CML suggest that there may also be a clonal Ph-negative stage in CML and that the Ph-positive stage arises by subclonal expansion. To determine whether this is a frequent or a rare occurrence, 14 additional glucose-6-phosphate dehydrogenase (G6PD)-heterozygous patients with CML were studied. In five of those patients there was a statistically significant excess of Ph-negative B-lymphoid cell lines expressing the same G6PD type expressed in the corresponding CML clone. In no case was an excess of B-lymphoid lines expressing the opposite G6PD type recovered. These data provide further evidence that in some patients the Ph chromosome arises in a pluripotent stem cell from a pre-existing Ph-negative clone that enjoys a growth advantage. |
| Document Type: Article |
| Language: English |
| Reprint Address: RASKIND, WH (reprint author), UNIV WASHINGTON, SCH MED, DEPT MED RG25, SEATTLE, WA 98195 USA |
Addresses:
1. UNIV GENOA, INST ONCOL CLIN & SPERIMENTALE, I-16126 GENOA, ITALY
2. MT SINAI MED CTR, TUMOR CYTOGENET, NEW YORK, NY 10029 USA
3. GEORGETOWN UNIV, DEPT HEMATOL, WASHINGTON, DC 20007 USA
4. SUNY DOWNSTATE MED CTR, HLTH SCI CTR, BROOKLYN, NY USA |
| Publisher: STOCKTON PRESS, HOUNDMILLS, BASINGSTOKE, HAMPSHIRE, ENGLAND RG21 6XS |
| Subject Category: Oncology; Hematology |
| IDS Number: LU159 |
| ISSN: 0887-6924 |
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