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| BCL-X, A BCL-2-RELATED GENE THAT FUNCTIONS AS A DOMINANT REGULATOR OF APOPTOTIC CELL-DEATH |
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| Author(s): BOISE LH, GONZALEZGARCIA M, POSTEMA CE, DING LY, LINDSTEN T, TURKA LA, MAO XH, NUNEZ G, THOMPSON CB |
| Source: CELL Volume: 74 Issue: 4 Pages: 597-608 Published: AUG 27 1993 |
| Times Cited: 2,336 References: 43 |
| Abstract: We report the isolation of bcl-x, a bcl-2-related gene that can function as a bcl-2-independent regulator of programed cell death (apoptosis). Alternative splicing results in two distinct bcl-x mRNAs. The protein product of the larger mRNA, bcl-x(L), is similar in size and predicted structure to Bcl-2. When stably transfected into an IL-3-dependent cell line, bcl-x(L) inhibits cell death upon growth factor with drawal at least as well as bcl-2. Surprisingly, the second mRNA species, bcl-x(s), encodes a protein that inhibits the ability of bcl-2 to enhance the survival of growth factor-deprived cells. In vivo, bcl-x(s) mRNA is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, bcl-x(L) is found in tissues containing long-lived postmitotic cells, such as adult brain. Together these data suggest that bcl-x plays an important role in both positive and negative regulation of programed cell death. |
| Document Type: Article |
| Language: English |
| Reprint Address: BOISE, LH (reprint author), UNIV CHICAGO, HOWARD HUGHES MED INST, DEPT MED, CHICAGO, IL 60637 USA |
Addresses:
1. UNIV CHICAGO, HOWARD HUGHES MED INST, DEPT MOLEC GENET & CELL BIOL, CHICAGO, IL 60637 USA
2. UNIV MICHIGAN, SCH MED, DEPT PATHOL, ANN ARBOR, MI 48109 USA
3. UNIV MICHIGAN, SCH MED, DEPT MED, ANN ARBOR, MI 48109 USA |
| Publisher: CELL PRESS, 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: LU592 |
| ISSN: 0092-8674 |
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