| | |  | | | | Record from Web of Science® | | | | | | |
| FROM CADHERINS TO CATENINS - CYTOPLASMIC PROTEIN INTERACTIONS AND REGULATION OF CELL-ADHESION |
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| Author(s): KEMLER R |
| Source: TRENDS IN GENETICS Volume: 9 Issue: 9 Pages: 317-321 Published: SEP 1993 |
| Times Cited: 706 References: 42 |
| Abstract: Classical cadherins are complexed via their cytoplasmic domains with alpha-, beta- and gamma-catenin. This complex formation links cadherins to the actin filament network and to other transmembrane and cytoplasmic proteins. Alpha-catenin is homologous to vinculin, and beta-catenin to the product of the Drosophila gene armadillo, while gamma-catenin seems to be identical to plakoglobin. Catenins are part of a higher order protein structure that is of crucial importance for the adhesive function of cadberins. A working model of the construction and regulation of this multiprotein interaction is proposed. |
| Document Type: Review |
| Language: English |
| Reprint Address: KEMLER, R (reprint author), MAX PLANCK INST IMMUNBIOL, STUBEWEG 51, W-7800 FREIBURG, GERMANY |
| Publisher: ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB |
| Subject Category: Genetics & Heredity |
| IDS Number: LU770 |
| ISSN: 0168-9525 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |