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| CLONING OF AN MYCOBACTERIUM-TUBERCULOSIS DNA FRAGMENT ASSOCIATED WITH ENTRY AND SURVIVAL INSIDE CELLS |
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| Author(s): ARRUDA S, BOMFIM G, KNIGHTS R, HUIMABYRON T, RILEY LW |
| Source: SCIENCE Volume: 261 Issue: 5127 Pages: 1454-1457 Published: SEP 10 1993 |
| Times Cited: 173 References: 12 |
| Abstract: Mycobacterium tuberculosis infects one-third of the world's human population. This widespread infection depends on the organism's ability to escape host defenses by gaining entry and surviving inside the macrophage. DNA sequences of M. tuberculosis have been cloned; these confer on a nonpathogenic Escherichia coli strain an ability to invade HeLa cells, augment macrophage phagocytosis, and survive for at least 24 hours inside the human macrophage. This capacity to gain entry into mammalian cells and survive inside the macrophage was localized to two distinct loci on the cloned M. tuberculosis DNA fragment. |
| Document Type: Article |
| Language: English |
Addresses:
1. CORNELL UNIV, MED CTR, COLL MED, DIV INT MED, NEW YORK, NY 10021 USA
2. NEW YORK BLOOD CTR, NEW YORK, NY 10021 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: LW549 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |