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| POLYKETIDE SYNTHESIS - PROSPECTS FOR HYBRID ANTIBIOTICS |
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| Author(s): KATZ L, DONADIO S |
| Source: ANNUAL REVIEW OF MICROBIOLOGY Volume: 47 Pages: 875-912 Published: 1993 |
| Times Cited: 289 References: 135 |
| Abstract: Polyketides fall into two structural classes: aromatic and complex. The former are built mainly from acetate units through a reiterative process wherein the beta-carbonyl groups formed after each condensation cycle are left largely unreduced. Complex polyketides are composed of acetates, propionates, or butyrates, and the extent of beta-carbonyl reduction varies from one cycle to the next. Two themes for polyketide synthases are emerging. Aromatic PKSs are determined by four to six genes encoding mono- or bifunctional enzymes; one PKS complex is used for all synthesis steps. Complex PKSs are composed of several mulitfunctional polypeptides that contain enzymatic domains for the condensation and reduction steps; each domain is used at a unique step in the pathways, and the extent of beta-carbonyl processing depends on the functional domains operating at that cycle. Mutations rendering certain domains nonfunctional have been introduced into genes for complex polyketides, resulting in the production of novel molecules. |
| Document Type: Review |
| Language: English |
| Reprint Address: KATZ, L (reprint author), ABBOTT LABS, ABBOTT PK, IL 60064 USA |
| Publisher: ANNUAL REVIEWS INC, 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0139 |
| Subject Category: Microbiology |
| IDS Number: MA276 |
| ISSN: 0066-4227 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |