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| RENDERING A MEMBRANE-PROTEIN SOLUBLE IN WATER - A COMMON PACKING MOTIF IN BACTERIAL PROTEIN TOXINS |
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| Author(s): PARKER MW, PATTUS F |
| Source: TRENDS IN BIOCHEMICAL SCIENCES Volume: 18 Issue: 10 Pages: 391-395 Published: OCT 1993 |
| Times Cited: 109 References: 23 |
| Abstract: The recently determined structures of three different protein toxins by X-ray crystallography has unexpectedly revealed a common membrane-insertion domain. This domain consists of an alpha-helical bundle of between seven and ten helices, some of which are hydrophobic. The three toxins, colicin, insecticidal delta-endotoxin and diphtheria toxin are directed towards different hosts, have different killing mechanisms and bear no sequence homology. The observation of a common membrane-insertion domain has implications for the design of therapeutic agents in combating disease. |
| Document Type: Review |
| Language: English |
| Reprint Address: PARKER, MW (reprint author), ST VINCENTS INST MED RES, 41 VICTORIA PARADE, FITZROY, VIC 3065 AUSTRALIA |
Addresses:
1. EUROPEAN MOLEC BIOL LAB, D-69012 HEIDELBERG, GERMANY |
| Publisher: ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB |
| Subject Category: Biochemistry & Molecular Biology |
| IDS Number: MB668 |
| ISSN: 0968-0004 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |