| INTERACTION OF THE NATURAL ANTI-GAL ANTIBODY WITH ALPHA-GALACTOSYL EPITOPES - A MAJOR OBSTACLE FOR XENOTRANSPLANTATION IN HUMANS |
|
|
| Author(s): GALILI U |
| Source: IMMUNOLOGY TODAY Volume: 14 Issue: 10 Pages: 480-482 Published: OCT 1993 |
| Times Cited: 439 References: 30 |
| Abstract: Cells of nonprimate mammals express an abundance of the carbohydrate structure Galalpha1-3Galbeta1-4GlcNAc-R (termed the alpha-galactosyl epitope). The natural anti-Gal antibody, which interacts specifically with alpha-galactosyl epitopes, is present in high concentrations in alt humans. Here, Uri Galili argues that the interaction between anti-Gal in the serum and alpha-galactosyl epitopes on celts of nonprimate grafts may act as an immunological barrier which prevents xenotransplantation. |
| Document Type: Editorial Material |
| Language: English |
| Reprint Address: GALILI, U (reprint author), MED COLL PENN, DEPT MICROBIOL & IMMUNOL, PHILADELPHIA, PA 19129 USA |
| Publisher: ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB |
| Subject Category: Immunology |
| IDS Number: MC811 |
| ISSN: 0167-5699 |