| | |  | | | | Record from Web of Science® | | | | | | |
| IN-SITU LABELING OF GRANULE CELLS FOR APOPTOSIS-ASSOCIATED DNA FRAGMENTATION REVEALS DIFFERENT MECHANISMS OF CELL LOSS IN DEVELOPING CEREBELLUM |
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| Author(s): WOOD KA, DIPASQUALE B, YOULE RJ |
| Source: NEURON Volume: 11 Issue: 4 Pages: 621-632 Published: OCT 1993 |
| Times Cited: 281 References: 39 |
| Abstract: We have examined the role apoptosis plays during postnatal development of the mouse cerebellum by a new method utilizing T7 DNA polymerase for the in situ detection of DNA fragmentation associated with cell death. Granule cell loss between the third and fifth postnatal weeks, hypothesized to affect the granule cell to Purkinje cell stoichiometry, is not associated with DNA fragmentation. However, cerebellar granule cells undergo extensive nuclear DNA fragmentation between postnatal days 5 and 9. Cell death prior to synaptogenesis may help regulate granule cell number. Our results suggest that different mechanisms of cell death within the same neuronal cell population occur during development. |
| Document Type: Article |
| Language: English |
| Reprint Address: WOOD, KA (reprint author), NINCDS, BIOCHEM SECT, SURG NEUROL BRANCH, BETHESDA, MD 20892 USA |
| Publisher: CELL PRESS, 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 |
| Subject Category: Neurosciences |
| IDS Number: MD068 |
| ISSN: 0896-6273 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |