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| GENETIC INSTABILITY IN PANCREATIC-CANCER AND POORLY DIFFERENTIATED TYPE OF GASTRIC-CANCER |
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| Author(s): HAN HJ, YANAGISAWA A, KATO Y, PARK JG, NAKAMURA Y |
| Source: CANCER RESEARCH Volume: 53 Issue: 21 Pages: 5087-5089 Published: NOV 1 1993 |
| Times Cited: 479 References: 19 |
| Abstract: To examine genetic instability during carcinogenesis, we screened 171 carcinomas of the breast, liver, proximal colon, stomach, pancreas, uterine cervix, and ovary for replication error at four microsatellite marker loci on chromosomes 2, 3, and 17. A significantly high incidence of genetic instability was observed in pancreatic (6 of 9 tumors) and gastric cancers (22 of 57 cases). In other types of carcinoma, the incidence of replication error-positive cases was relatively low (3-16%). Among gastric carcinomas, significantly more replication error-positive cases were observed in the poorly differentiated types (16 of 25 cases) than in well differentiated types (3 of 18) (P = 0.0023 by Fisher's exact test). Our results suggested that genetic instability is likely to play an important role in development of pancreatic and gastric cancers, particularly poorly differentiated adenocarcinomas. |
| Document Type: Note |
| Language: English |
Addresses:
1. JAPANESE FDN CANC RES, INST CANC, DEPT BIOCHEM, 1-37-1 KAMI IKEBUKURO, TOSHIMA KU, TOKYO 170, JAPAN
2. SEOUL NATL UNIV, COLL MED, CANC RES INST, TUMOR CELL BIOL LAB, SEOUL 110744, SOUTH KOREA
3. JAPANESE FDN CANC RES, INST CANC, DEPT PATHOL, TOKYO 170, JAPAN |
| Publisher: AMER ASSOC CANCER RESEARCH, 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA |
| Subject Category: Oncology |
| IDS Number: MD950 |
| ISSN: 0008-5472 |
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