| GENETIC-MAPPING OF A 2ND LOCUS PREDISPOSING TO HEREDITARY NONPOLYPOSIS COLON-CANCER |
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| Author(s): LINDBLOM A, TANNERGARD P, WERELIUS B, NORDENSKJOLD M |
| Source: NATURE GENETICS Volume: 5 Issue: 3 Pages: 279-282 Published: NOV 1993 |
| Times Cited: 365 References: 22 |
| Abstract: Hereditary colon cancer is caused by mutations in several different loci. The APC gene on chromosome 5 causing adenomatous polyposis coli represents a minority of the inherited colon cancer cases, while hereditary-non polyposis colon cancer (HNPCC) may cause five percent of all human colon cancer. One gene causing HNPCC was recently mapped to chromosome 2 but the same study also showed that at least one additional locus may cause HNPCC. We now present tight linkage between a polymorphic marker on the short arm of chromosome 3 and the disease locus, and find that these families also manifest signs of a general DNA replication disorder. |
| Document Type: Article |
| Language: English |
| Reprint Address: LINDBLOM, A (reprint author), KAROLINSKA HOSP, DEPT CLIN GENET, S-10401 STOCKHOLM 60, SWEDEN |
| Publisher: NATURE PUBLISHING CO, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 |
| Subject Category: Genetics & Heredity |
| IDS Number: MF122 |
| ISSN: 1061-4036 |