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| DEVELOPMENTAL ANALYSIS OF HIPPOCAMPAL MOSSY FIBER OUTGROWTH IN A MUTANT MOUSE WITH INHERITED SPIKE-WAVE SEIZURES |
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| Author(s): QIAO XX, NOEBELS JL |
| Source: JOURNAL OF NEUROSCIENCE Volume: 13 Issue: 11 Pages: 4622-4635 Published: NOV 1993 |
| Times Cited: 76 References: 87 |
| Abstract: Neural firing patterns are an essential determinant of normal axon terminal growth and synaptic connectivity in developing afferent pathways, but the trophic role of synchronous activity in associative neural networks is less well defined. We examined the ontogeny of inherited synchronous hippocampal network discharges and mossy fiber innervation patterns at sequential stages of development in the stargazer(stg) mutant, a single-locus mouse mutation expressing generalized spike-wave epilepsy. Brief bursts of 6/sec repetitive discharges arise spontaneously on postnatal days 17-18 and persistently activate neocortical and hippocampal networks throughout adulthood. We found a striking pattern of mossy fiber recurrent axon collateral sprouting in the inner molecular layer of dentate gyrus in the adult stg hippocampus. Sprouting is.not apparent until 4-6 weeks following seizure onset, but then steadily intensifies with continued synchronous activation. In the adult mutant, axon outgrowth is accompanied by a mild selective loss of hilar interneurons without gliosis. These data indicate that hypersynchronous stimulation during late postnatal brain development is linked, following a prolonged latent period, to significant fiber outgrowth and synaptic reorganization within the hippocampal formation. Since the pattern of synchronous activation in the stg mutant strongly resembles that seen in human spike-wave absence epilepsy, the synaptic plasticity described in this model has important implications for normal brain development in this common disorder. |
| Document Type: Article |
| Language: English |
Addresses:
1. BAYLOR COLL MED, DEPT NEUROL, DIV NEUROSCI, NEUROPHYSIOL SECT, DEV NEUROGENET LAB, 1 BAYLOR PLAZA, HOUSTON, TX 77030 USA
2. BAYLOR COLL MED, INST MOLEC GENET, HOUSTON, TX 77030 USA |
| Publisher: SOC NEUROSCIENCE, 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 |
| Subject Category: Neurosciences |
| IDS Number: MF297 |
| ISSN: 0270-6474 |
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