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| CRYOGLOBULINEMIC MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS ASSOCIATED WITH HEPATITIS-C VIRUS |
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| Author(s): PASQUARIELLO A, FERRI C, MORICONI L, LACIVITA L, LONGOMBARDO G, LOMBARDINI F, GRECO F, ZIGNEGO AL |
| Source: AMERICAN JOURNAL OF NEPHROLOGY Volume: 13 Issue: 4 Pages: 300-304 Published: JUL-AUG 1993 |
| Times Cited: 48 References: 22 |
| Abstract: A striking association between hepatitis C virus (HCV) and mixed cryoglobulinemia (MC) has been reported by various authors, regardless of the presence of chronic hepatitis. The aim of this study is to evaluate the prevalence of HCV-related markers in cryoglobulinemic membranoproliferative glomerulonephritis (MPGN) which is one of the most severe complications of MC. Antibodies against HCV have been detected by second-generation Chiron ELISA and RIBA in 26/26 (100%) cryoglobulinemic MPGN. In addition, serum HCV RNA, expression of the ongoing viral replication, was present in 7/7 patients by the polymerase chain reaction technique. The high percentage of anti-HCV seropositivity suggests that this virus may play an important role in the pathogenesis of this immunemediated glomerulonephritis. |
| Document Type: Letter |
| Language: English |
| Reprint Address: PASQUARIELLO, A (reprint author), OSPED S CHIARA, DIV NEFROL, VIA ROOM 67, I-56100 PISA, ITALY |
Addresses:
1. SANTA CHIARA HOSP, CTR BLOOD, I-56100 PISA, ITALY
2. UNIV PISA, RHEUMATOL & CLIN IMMUNOL UNIT, I-56100 PISA, ITALY
3. UNIV FLORENCE, INST CLIN MED 2, I-50121 FLORENCE, ITALY |
| Publisher: KARGER, ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND |
| Subject Category: Urology & Nephrology |
| IDS Number: MF468 |
| ISSN: 0250-8095 |
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