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| DISRUPTION OF THE HOXD-13 GENE INDUCES LOCALIZED HETEROCHRONY LEADING TO MICE WITH NEOTENIC LIMBS |
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| Author(s): DOLLE P, DIERICH A, LEMEUR M, SCHIMMANG T, SCHUHBAUR B, CHAMBON P, DUBOULE D |
| Source: CELL Volume: 75 Issue: 3 Pages: 431-441 Published: NOV 5 1993 |
| Times Cited: 340 References: 62 |
| Abstract: Vertebrate Hoxd genes are sequentially activated during the morphogenesis and pattern formation of the limb. Using the approach of gene disruption via homologous recombination in embryonic stem cells, we have assessed the function of the last gene of the complex, Hoxd-13. Mutant mice displayed skeletal alterations along all body axes suggesting the existence of a general multiaxial patterning system. In limbs, abnormalities such as a reduction in the length of some bony elements, loss of phalanges, bone fusions, and the presence of an extra element were observed. We propose that the mutation induces local heterochrony, as illustrated by an important retardation in limb-morphogenesis. The relevance of these observations to our understanding of the development and evolution of the tetrapod limb is discussed. |
| Document Type: Article |
| Language: English |
| Reprint Address: DOLLE, P (reprint author), FAC MED STRASBOURG, CNRS, GENET MOLEC EUCARYOTES, INSERM, U184, 11 RUE HUMANN, F-67085 STRASBOURG, FRANCE |
Addresses:
1. EUROPEAN MOLEC BIOL LAB, W-6900 HEIDELBERG 1, GERMANY |
| Publisher: CELL PRESS, 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: MF830 |
| ISSN: 0092-8674 |
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