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| FGF-4 REPLACES THE APICAL ECTODERMAL RIDGE AND DIRECTS OUTGROWTH AND PATTERNING OF THE LIMB |
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| Author(s): NISWANDER L, TICKLE C, VOGEL A, BOOTH I, MARTIN GR |
| Source: CELL Volume: 75 Issue: 3 Pages: 579-587 Published: NOV 5 1993 |
| Times Cited: 476 References: 40 |
| Abstract: The apical ectodermal ridge plays a key role in limb development. We show that recombinant FGF-4 can substitute for the ridge to provide all the signals necessary for virtually complete outgrowth and patterning of the chick limb. FGF-4 stimulates proliferation of cells in the distal mesenchyme and maintains a signal from the posterior to the distal mesenchyme that appears to be required for elaboration of skeletal elements in the normal proximodistal sequence. Moreover, retinoic acid, which is capable of providing polarizing activity, can supply this signal. This suggests that polarizing activity plays a role in patterning along the proximodistal axis, in addition to its well-established role in anteroposterior patterning. Taken together, the data suggest a simple mechanism whereby FGF-4 links growth and pattern formation during limb development. |
| Document Type: Article |
| Language: English |
| Reprint Address: NISWANDER, L (reprint author), UNIV CALIF SAN FRANCISCO, SCH MED, DEPT ANAT, SAN FRANCISCO, CA 94143 USA |
Addresses:
1. UNIV CALIF SAN FRANCISCO, PROGRAM DEV BIOL, SAN FRANCISCO, CA 94143 USA
2. UNIV COLL & MIDDLESEX SCH MED, DEPT ANAT & DEV BIOL, LONDON W1P 6DB, ENGLAND |
| Publisher: CELL PRESS, 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: MF830 |
| ISSN: 0092-8674 |
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