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| CORRELATION BETWEEN MAGNETIC-RESONANCE-IMAGING FINDINGS AND LESION DEVELOPMENT IN CHRONIC, ACTIVE MULTIPLE-SCLEROSIS |
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| Author(s): KATZ D, TAUBENBERGER JK, CANNELLA B, MCFARLIN DE, RAINE CS, MCFARLAND HF |
| Source: ANNALS OF NEUROLOGY Volume: 34 Issue: 5 Pages: 661-669 Published: NOV 1993 |
| Times Cited: 288 References: 29 |
| Abstract: Magnetic resonance imaging is a highly sensitive method for the detection of the lesions of multiple sclerosis an renders possible the study and the evolution of early lesions. Previous reports on magnetic resonance imaging following gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) injection demonstrated that new lesions can be recognized by contrast enhancement. The pathological basis of these observations is uncertain. We have had the opportunity to study at autopsy the brain of a patient with chronic progressive multiple sclerosis who suffered acute worsening leading to death. Magnetic resonance imaging performed 10 days and 4 weeks prior to death showed new Gd-DTPA-enhanced lesions in the posterior hemispheric white matter adjacent to the lateral ventricles. Light microscopic examination of these areas demonstrated them to be fresh lesions comprising intense inflammatory activity and dense perivascular cuffs within an edematous lesion center and a striking parenchymal mononuclear cell infiltration at the margins of the lesions. Lesions that were demonstrated by increased signal on T2-weighted images, but were not enhanced following administration of Gd-DTPA, were all of the chronic type, either inactive or active. None of these showed the intense inflammatory activity of the acute lesions and most displayed fibrous astrogliosis. |
| Document Type: Article |
| Language: English |
Addresses:
1. NCI, PATHOL LAB, BETHESDA, MD 20892 USA
2. YESHIVA UNIV ALBERT EINSTEIN COLL MED, DEPT PATHOL NEUROPATHOL, BRONX, NY 10461 USA
3. YESHIVA UNIV ALBERT EINSTEIN COLL MED, DEPT NEUROL, BRONX, NY 10461 USA
4. YESHIVA UNIV ALBERT EINSTEIN COLL MED, DEPT NEUROSCI, BRONX, NY 10461 USA
5. ROSE F KENNEDY CTR RES MENTAL RETARDAT & HUMAN DEV, BRONX, NY USA
6. NIH, NEUROIMMUNOL BRANCH, BETHESDA, MD 20892 USA
7. NINCDS, OFF CLIN DIRECTOR, BETHESDA, MD 20892 USA |
| Publisher: LITTLE BROWN CO, 34 BEACON STREET, BOSTON, MA 02108-1493 |
| Subject Category: Clinical Neurology; Neurosciences |
| IDS Number: MG096 |
| ISSN: 0364-5134 |
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