| | |  | | | | Record from Web of Science® | | | | | | |
| GENETIC IDENTIFICATION OF MOM-1, A MAJOR MODIFIER LOCUS AFFECTING MIN-INDUCED INTESTINAL NEOPLASIA IN THE MOUSE |
|
|
| Author(s): DIETRICH WF, LANDER ES, SMITH JS, MOSER AR, GOULD KA, LUONGO C, BORENSTEIN N, DOVE W |
| Source: CELL Volume: 75 Issue: 4 Pages: 631-639 Published: NOV 19 1993 |
| Times Cited: 517 References: 48 |
| Abstract: Mutations in the human APC gene cause various familial colon cancer syndromes. The Multiple intestinal neoplasia (Min) mouse provides an excellent model for familial colon cancer: it carries a mutant mouse Apc gene and develops many intestinal adenomas. Here, we analyze how this tumor phenotype is dramatically modified by genetic background. We report the genetic mapping of a locus that strongly modifies tumor number in Min/+ animals. This gene, Mom-1 (Modifier of Min-1), maps to distal chromosome 4 and controls about 50% of genetic variation in tumor number in two intraspecific backcrosses. The mapping is supported by a LOD score exceeding 14. Interestingly, Mom-1 lies in a region of synteny conservation with human chromosome 1p35-36, a region of frequent somatic loss of heterozygosity in a variety of human tumors, including colon tumors. These results provide evidence of a major modifier affecting expression of an inherited cancer syndrome. |
| Document Type: Article |
| Language: English |
| Reprint Address: DIETRICH, WF (reprint author), MIT, WHITEHEAD INST BIOMED RES, CAMBRIDGE, MA 02142 USA |
Addresses:
1. MIT, DEPT BIOL, CAMBRIDGE, MA 02142 USA
2. UNIV WISCONSIN, GENET LAB, MADISON, WI 53706 USA
3. UNIV WISCONSIN, MCARDLE LAB CANC RES, MADISON, WI 53706 USA |
| Publisher: CELL PRESS, 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: MH749 |
| ISSN: 0092-8674 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |