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| PROSPECTS FOR CLINICALLY TOLERATED NMDA ANTAGONISTS - OPEN-CHANNEL BLOCKERS AND ALTERNATIVE REDOX STATES OF NITRIC-OXIDE |
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| Author(s): LIPTON SA |
| Source: TRENDS IN NEUROSCIENCES Volume: 16 Issue: 12 Pages: 527-532 Published: DEC 1993 |
| Times Cited: 209 References: 69 |
| Abstract: Several acute and chronic neurological diseases might be mediated, at least in part, via stimulation of excitatory amino acid receptors, such as the N-methyl-D-aspartate (NMDA) receptor. Antagonists of excitatory amino acid receptors ameliorate neurotoxic damage in several animal models of these disorders. This review focuses on the potential for clinically tolerated NMDA receptor antagonists, with emphasis on agents that have been in clinical use for other conditions and that recently have been shown to inhibit NMDA receptor activity by a mechanism of open-channel block or redox modification. |
| Document Type: Article |
| Language: English |
| Reprint Address: LIPTON, SA (reprint author), CHILDRENS HOSP MED CTR, DEPT NEUROL, CELLULAR & MOLEC LAB, BOSTON, MA 02115 USA |
Addresses:
1. BETH ISRAEL HOSP, DEPT NEUROL, BOSTON, MA 02215 USA
2. BRIGHAM & WOMENS HOSP, DEPT NEUROL, BOSTON, MA 02115 USA
3. HARVARD UNIV, MASSACHUSETTS GEN HOSP, SCH MED, DEPT NEUROL, BOSTON, MA 02114 USA |
| Publisher: ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB |
| Subject Category: Neurosciences |
| IDS Number: MK097 |
| ISSN: 0166-2236 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |