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| GLOMERULOSCLEROSIS INDUCED BY IN-VIVO TRANSFECTION OF TRANSFORMING GROWTH-FACTOR-BETA OR PLATELET-DERIVED GROWTH-FACTOR GENE INTO THE RAT-KIDNEY |
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| Author(s): ISAKA Y, FUJIWARA Y, UEDA N, KANEDA Y, KAMADA T, IMAI E |
| Source: JOURNAL OF CLINICAL INVESTIGATION Volume: 92 Issue: 6 Pages: 2597-2601 Published: DEC 1993 |
| Times Cited: 453 References: 23 |
| Abstract: Glomerulosclerosis, a final common lesion of various glomerular diseases, is characterized by mesangial cell proliferation and extracellular matrix (ECM) expansion. TGF-beta and PDGF are known to play a critical role in the regulation of FCM metabolism and mesenchymal cell proliferation, respectively. However, there is little evidence to demonstrate the direct role of each of these growth factors in the pathogenesis of glomerulosclerosis. Using an in vivo transfection technique, we could realize the selective overexpression of single growth factor in the kidney. The introduction of either TGF-beta or PDGF-B gene alone into the kidney induced glomerulosclerosis, although the patterns of action of these growth factors were different; TGF-beta affected ECM accumulation rather than cell proliferation and PDGF affected the latter rather than the former. |
| Document Type: Article |
| Language: English |
Addresses:
1. OSAKA UNIV, SCH MED, DEPT MED 1, 2-2 YAMADA OKA, SUITA, OSAKA 565 JAPAN
2. OSAKA UNIV, INST MOLEC & CELLULAR BIOL, SUITA, OSAKA 565 JAPAN |
| Publisher: ROCKEFELLER UNIV PRESS, 1114 FIRST AVE, 4TH FL, NEW YORK, NY 10021 |
| Subject Category: Medicine, Research & Experimental |
| IDS Number: ML643 |
| ISSN: 0021-9738 |
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