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| LONG-TERM POTENTIATION AND LONG-TERM DEPRESSION OF PRIMARY AFFERENT NEUROTRANSMISSION IN THE RAT SPINAL-CORD |
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| Author(s): RANDIC M, JIANG MC, CERNE R |
| Source: JOURNAL OF NEUROSCIENCE Volume: 13 Issue: 12 Pages: 5228-5241 Published: DEC 1993 |
| Times Cited: 291 References: 96 |
| Abstract: Synaptic transmission between dorsal root afferents and neurons in the superficial laminae of the spinal dorsal horn (laminae I-III) was examined by intracellular recording in a transverse slice preparation of rat spinal cord. Brief high-frequency electrical stimulation (300 pulses at 100 Hz) of primary afferent fibers produced a long-term potentiation (LTP) or a long-term depression (LTD) of fast (monosynaptic and polysynaptic) EPSPs in a high proportion of dorsal horn neurons. Both the AMPA and the NMDA receptor-mediated components of synaptic transmission at the primary afferent synapses with neurons in the dorsal horn can exhibit LTP and LTD of the synaptic responses. In normal and neonatally capsaicin-treated rats, the induction of LTP requires the activation of NMDA receptor-gated conductances. The induction of LTP or LTD, however, was not abolished in the presence of bicuculline, a GABA(A) receptor antagonist. The results demonstrate that distinct and long-lasting modulation in synaptic efficiency can be induced at primary afferent synapses with neurons in the superficial laminae of spinal dorsal horn by high-frequency stimulation of dorsal root afferents and that these changes may be physiologically relevant for transmission and integration of sensory information, including pain. |
| Document Type: Article |
| Language: English |
| Reprint Address: RANDIC, M (reprint author), IOWA STATE UNIV SCI & TECHNOL, DEPT VET PHYSIOL & PHARMACOL, AMES, IA 50011 USA |
| Publisher: SOC NEUROSCIENCE, 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 |
| Subject Category: Neurosciences |
| IDS Number: MN040 |
| ISSN: 0270-6474 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |